Sirtuins at the Breaking Point: SIRT6 in DNA Repair
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چکیده
منابع مشابه
Sirtuins at the Breaking Point: SIRT6 in DNA Repair
is the accumulation of unrepaired damage to cellular and organismal components over time. Damage to nuclear DNA likely contributes to the degenerative effects of aging; unlike other cellular constituents, nuclear DNA cannot be replaced [1]. A wide spectrum of DNA lesions and associated repair pathways exist [1]: non-helix distorting lesions, such as those induced by oxidative damage, are repair...
متن کاملSIRT6 in DNA repair, metabolism and ageing.
Ageing, or increased mortality with time, coupled with physiologic decline, is a nearly universal yet poorly understood biological phenomenon. Studies in model organisms suggest that two conserved pathways modulate longevity: DNA damage repair and Insulin/Igf1-like signalling. In addition, homologs of yeast Sir2--the sirtuins--regulate lifespan in diverse organisms. Here, we focus on one partic...
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The mammalian sirtuin family has attracted tremendous attention over the past few years as stress adaptors and post-translational modifier. They have involved in diverse cellular processes including DNA repair, energy metabolism, and tumorigenesis. Notably, genomic instability and metabolic reprogramming are two of characteristic hallmarks in cancer. In this review, we summarize current knowled...
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The Sir2 chromatin regulatory factor links maintenance of genomic stability to life span extension in yeast. The mammalian Sir2 family member SIRT6 has been proposed to have analogous functions, because SIRT6-deficiency leads to shortened life span and an aging-like degenerative phenotype in mice, and SIRT6 knockout cells exhibit genomic instability and DNA damage hypersensitivity. However, the...
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The sirtuin gene family comprises an evolutionarily ancient set of NAD+ dependent protein deacetylase and mono-ADP ribosyltransferase enzymes. Found in all domains of life, sirtuins regulate a diverse array of biological processes, including DNA repair, gene silencing, apoptosis and metabolism. Studies in multiple model organisms have indicated that sirtuins may also function to extend lifespan...
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ژورنال
عنوان ژورنال: Aging
سال: 2009
ISSN: 1945-4589
DOI: 10.18632/aging.100014